World-First Antibody-Drug Supply System Developed Utilizing Supercharged Man-Made Crystals

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MOF Antibody Crystals Seek Out Cancer Cells

Schematic illustration of the brand new MOF Antibody crystals and their capability to particularly hunt down most cancers cells to detect them and ship extremely potent medicine with unprecedented precision. Credit score: Dr. Francesco Carraro and Prof. Paolo Falcaro (Co-First and Co-Senior writer on the Superior Supplies Paper)

It sounds just like the stuff of science fiction: a man-made crystal that may be hooked up to antibodies after which supercharge them with potent medicine or imaging brokers that may hunt down diseased cells with the best precision, leading to fewer adversarial results for the affected person.

Nevertheless, that’s exactly what researchers from the Australian Centre for Blood Illnesses at Monash College in collaboration with the TU Graz (Austria) have developed: the world’s first metal-organic framework (MOFs) antibody-drug delivery system that has the potential to fast-track potent new therapies for cancer, cardiovascular and autoimmune diseases.

The in vitro study showed that when MOF antibody crystals bind to their target cancer cells and if exposed to the low pH in the cells, they break down, delivering the drugs directly and solely to the desired area.

The metal-organic framework, a mixture of metal (zinc) and carbonate ions, and a small organic molecule (an imidazole, a colorless solid compound that is soluble in water) not only keeps the payload attached to the antibody but can also acts as a reservoir of personalized therapeutics. This is a benefit with the potential to become a new medical tool to target specific diseases with customized drugs and optimized doses.

The findings are now published in the world-leading journal Advanced Materials.

Co-senior author Professor Christoph Hagemeyer, Head of the NanoBiotechnology Laboratory at the Australian Centre for Blood Diseases, Monash University, says while more funding is needed to take the research into the next phase and to patients, the new method is cheaper, faster, and more versatile than anything available currently.

“The method offers the opportunity to personalize treatment and given the precision possible, may eventually change the current dosage needed for patients, resulting in fewer side effects and making treatments cheaper,” said Professor Hagemeyer.

Co-first author Dr. Karen Alt, Head of the Nano Theranostics Laboratory at the Australian Centre for Blood Diseases, Monash University, says: “With just 0.01 percent of chemotherapy currently reaching the cancer tissue, this revolutionary new method can boost the potency of the drugs reaching their target.”

“With over 80 different monoclonal antibodies approved for clinical use, this approach has enormous potential to improve these antibodies for the targeted delivery of diagnostic agents and therapeutic drugs. The goal is that ultimately the clinical translation of this technology will improve the quality of life for patients suffering from serious diseases,” said Dr. Alt.

Reference: “Self-Assembly of Oriented Antibody-Decorated Metal–Organic Framework Nanocrystals for Active-Targeting Applications” by Karen Alt, Francesco Carraro, Edwina Jap, Mercedes Linares-Moreau, Raffaele Riccò, Marcello Righetto, Marco Bogar, Heinz Amenitsch, Rania A. Hashad, Christian Doonan, Christoph E. Hagemeyer and Paolo Falcaro, 6 December 2021, Advanced Materials.
DOI: 10.1002/adma.202106607

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